Research
- Aregger M and Cowling VH (2012) E2F1-dependent methyl cap formation requires RNA pol II phosphorylation Cell Cycle 212 Jun 1;11(11) doi:10.4161/cc.20620
- Gonatopoulos-Pournatzis T, Dunn S, Bounds R, and Cowling VH (2011) RAM/Fam103a1 is required for mRNA cap methylation Molecular Cell 2011 Nov18;44(4):585-596 doi:10.1016/j.molcel.2011.08.041
- Cowling VH (2010) Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation Oncogene. 2010 Feb 11;29(6):930-6. Epub 2009 Nov 16. doi:10.1038/onc.2009.368
- Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, and Cowling VH (2009) S-Adenosyl Homocysteine Hydrolase (SAHH) is required for Myc-induced mRNA cap methylation, protein synthesis and cell proliferation Mol Cell Biol 2009, Dec;29(23):6182-91. Epub 2009 Oct 5. doi:10.1128/MCB.00973-09
- Cole MD and Cowling VH (2009) Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors Oncogene 2009 Mar 5;28(9):1169-75. Epub 2009 Jan 12. doi:10.1038/onc.2008.463
- Cowling VH and Cole MD (2007) The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA pol II Carboxy-terminal Domain Independently of Direct DNA Binding Mol Cell Biol, 2007 March; 27(6) p2059-2073 doi:10.1128/MCB.01828-06
Reviews
- Cole MD and Cowling VH (2008) Transcription-independent functions of MYC: regulation of translation and DNA replication Nature Reviews Mol Cel Biol 2008 Oct; 9 (10):810-5. Epub 2008 Aug 13. doi:10.1038/nrm2467
- Cowling VH (2010) Myc upregulates mRNA cap methylation Biochemical Society transactions 2010 Dec;38(6):1598-601 doi:10.1042/BST0381598
- Cowling VH and Cole MD (2010) Myc regulation of mRNA cap methylation Genes and Cancer: Special Review Issue 2010 Jun;1(6):576-579. doi:10.1177/1947601910378025
- Cowling VH (2009) Regulation of mRNA cap methylation Biochemical Journal 2009, Biochem J. 2009 Dec 23;425(2):295-302. Review doi:10.1042/BJ20091352
Historical
- Chandriani S, Frengen E , Cowling VH, Whitfield ML, Perou C and Cole MD (2009) A Core MYC Gene Expression Signature is Prominent in Basal-like Breast Cancer but Only Partially Overlaps the Core Serum Response PLoS ONE 2009 Aug 19;4(8):e6693 doi:10.1371/journal.pone.0006693
- Cowling VH and Cole MD (2008) An N-Myc truncation analogous to c-Myc-S induces cell proliferation independently of transactivation but dependent on Myc Homology Box II Oncogene 2008 Feb 21;27(9):1327-32. Epub 2007 Aug 20 doi:10.1038/sj.onc.1210734
- Cowling VH and Cole MD (2007) Turning the tables: Myc activates Wnt in breast cancer Cell Cycle 2007 Aug;6(21):2625-7. Epub 2007 Aug 13 doi:10.4161/cc.6.21.4880
- Cowling VH, D’Cruz C, Chodosh L and Cole MD (2007) c-myc transforms human mammary epithelial cells through repression of DKK1 and SFRP1 and activation of Wnt signaling Mol Cell Biol, 2007 Jul;27(14):5135-46 doi:10.1128/MCB.02282-06
- Cowling VH and Cole MD (2007) E-Cadherin repression contributes to c-Myc induced epithelial cell transformation Oncogene, 2007 May 24; 26(24) p3582-86. Epub 2006 Dec 4 doi:10.1038/sj.onc.1210132
- Cowling VH and Cole MD (2007) HATs Off to Capping: A New Mechanism for Myc Cell Cycle, 2007 April 15; 6(8) p307-309 doi:10.4161/cc.6.8.4123
- Cowling VH and Cole MD (2007) The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA pol II Carboxy-terminal Domain Independently of Direct DNA Binding Mol Cell Biol, 2007 March; 27(6) p2059-2073 doi:10.1128/MCB.01828-06
- Li H, Cherukuri P, Cowling VH, Cole MD, Spinella M, Godwin A, Wells W and DiRenzo J (2007) Nestin is expressed in Putative Mammary Progenitors and is a Selective Marker of Basal Epithelial Breast Tumors Cancer Research 2007 Jan 15, 67(2):501-10 doi:10.1158/0008-5472.CAN-05-4571
- Cowling VH, Chandriani S, Whitfield ML, and Cole MD (2006) A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis and G2 arrest Mol Cell Biol 2006 June 6; 11 p4226-4329 doi:10.1128/MCB.01959-05
- Cowling VH and Cole MD (2006) Mechanism of Transcriptional Activation by the Myc Oncoproteins Seminars in Cancer Biology 2006 Aug4; 16(4) p242-252 doi:10.1016/j.semcancer.2006.08.001
- Nicke B, Bastien J, Khanna SJ, Warne PH, Beijersbergen RL, Cowling V, Bernards R, Ganesan TS, Downward J and Hancock DC (2005) Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells Mol Cell. 2005 Dec 9;20(5):673-85 doi:10.1016/j.molcel.2005.10.038
- Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J (2003) Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi J.Biol Chem. 2003 Dec 5;278(49):49417-27 doi:10.1074/jbc.M308659200
- Cowling V and Downward J (2002) Caspase-6 is the direct activator of caspase-8 in the cytochrome c initiated apoptosis pathway; absolute requirement for removal of the prodomain Cell Death Differ 9(10):1046-1056 doi:10.1038/sj.cdd.4401065